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The following message was posted to: PharmPK
t1/2= 0.693*V/Cl, so no change in Cl and an increase in t1/2
increase in volume as you suggested,
however I disagree that fu could be involved because if I assume you
talking about an oral dose then
AUC oral=Fa*Fg*Dose/fu*Clint, so a change in fu (here I believe you are
suggesting an increase in keeping with the increase in volume above)
have been reflected as a change in the AUC oral (a decrease)--unless
proportional to another change in the equation..
again, we observe that volume has increased so a decrease in fu
tissue or an
increase in Vtissue are indicated, right?
anyway, this would be a little easier to figure out if I knew the
route and if Cmax was lower and K smaller (less steep)?
What do you think?
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