Back to the Top
I would like to know how calculate the LOQ of a method using a
quadratic equation (Y = Ax2+ BX + C) and the equation of LOQ prediction:
LOQ = SD x 10 / IC
where: SD stands for the standard deviation of the intercept with the
axis of Y of several calibration curves built containing
concentrations of the drug near the presumed quantification limit.
The standard deviation can also be obtained from the analysis of a
suitable number of samples of the white; ic is the slope of the
I guess that equation (LOQ prediction) is very easy to apply in a
linear equation (Y = AX+B) but how to run in a quadratic equation?
Daniel Rossi de Campos
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (firstname.lastname@example.org)