- On 13 Jul 2005 at 09:49:50, Daniel Rossi (camposrossi.-a-.yahoo.com.br) sent the message

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Dear All,

I would like to know how calculate the LOQ of a method using a

quadratic equation (Y = Ax2+ BX + C) and the equation of LOQ prediction:

LOQ = SD x 10 / IC

where: SD stands for the standard deviation of the intercept with the

axis of Y of several calibration curves built containing

concentrations of the drug near the presumed quantification limit.

The standard deviation can also be obtained from the analysis of a

suitable number of samples of the white; ic is the slope of the

calibration curve;

I guess that equation (LOQ prediction) is very easy to apply in a

linear equation (Y = AX+B) but how to run in a quadratic equation?

Regards,

Daniel Rossi de Campos

Brazil

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