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The following message was posted to: PharmPK
Dear all,
Could any one give some information on calculating
enzyme kinetics (Vmax, Km) value using substrate
depletion approach (where non linear velocity
conditions exist)...literature references already
exist for calculating intrinsic clearance value using
substrate depletion approach, but i couldn't find how
to estimate Vmax, Km by the same approach...any
literature references in this regard are also
helpful..
with regards
SK. BASHA
SK. Jafar Sadik Basha
Drug Metabolism and Pharmacokinetics,
Discovery Research,
Dr.Reddy's Research Foundation,
Bollaram Road, Miyapur, Hyderabad-49
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