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The following message was posted to: PharmPK
Dear all,
I wish you all a happy and healty 2005!
does anyone know a source for the residual volumes of blood in various
mouse tissues such as brain, ovaries, liver, kidneys, etc.?
For example, brain tissue contains, dependent on the dissection and
rinsing
method 1-2% of blood. Consequently, if you find a very low amount in the
brain tissue, it might be attributal not to brain penetration of the
substance but to the residual "external" blood amount of this tissue.
any hint would be helpful,
Philip
Philip Lienau
Schering AG
Research Pharmacokinetics
Tel.: +49 - 30 - 468 - 18507
Fax: +49 - 30 - 468 - 12238
[One older reference for rats is Triplett, J.W. et al. (including db)
1985 J. Pharm.Sci., 74, 1007-9 - db]
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The following message was posted to: PharmPK
Dear Philip,
> does anyone know a source for the residual volumes of blood in various
> mouse tissues such as brain, ovaries, liver, kidneys, etc.?
[]
> [One older reference for rats is Triplett, J.W. et al. (including db)
> 1985 J. Pharm.Sci., 74, 1007-9 - db]
Perhaps you could refer to 'Physiological parameter values for
physiologically based pharmacokinetic models' by Brown et al.,
Toxicology
and Industrial Health, 13 (1997) 407-484. It not only summarizes mean
data
but also describes variability across lit. sources. {the Triplett paper
has
been cited BTW ;-}
Best regards,
Jeroen
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)