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The following message was posted to: PharmPK
Dear all,
Due to solubility problems we want to make a formulation containing
Capmul (mcm c8), Captex and cremophor and water (if possible). I am
looking for safety data for preclinical studies. Does anyone know were
to find toxicity data for these bioavailability enhancers? MSDS I
already have with a LD50 but I would like to perform multiple dose
studies up to 4 weeks.
Regards
Hester
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Dear Sirs,
We also need to know the answer to approximately the same things that
were asked by Hester in her inquiry which was posted on the internet"
"Due to solubility problems we want to make a formulation containing
Capmul (mcm c8), Captex and cremophor and water (if possible). I am
looking for safety data for preclinical studies. Does anyone know were
to find toxicity data for these bioavailability enhancers? MSDS I
already have with a LD50 but I would like to perform multiple dose
studies up to 4 weeks.
Regards
Hester"
However, our formulation is slightly different and we need to find
toxicity data for multiple doses of LD50 (also for studies up to
about 4 weeks). We need to know what dosage will be toxic enough to
cause the death of a rat or mouse: we are using Capmul MCM, Cremophor
IL, and Captex 355.
I was not able to access the MSDS for this.
Thank you in advance for your assistance.
Sincerely,
Sara Golany
D-Pharm Ltd.
e-mail: sgolany.-a-.dpharm.com
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