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Dear sir,
I would like to know,
1) What is the dissolution profile (in-vitro) desired for Simvastatin
tablets 20 mg to pass the Bioequivalence study with Zocor 20.
2) What are various methods to improve the dissolution of
Simvastatin, without affecting the stability ?
3) how, simvastatin can be analysed by spectrophotometrical method of
analysis ?
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1.Dissolution profile of zocor 20 is that tablet dissolve in 30 min.
2.you can increase the solubility of simvastatin by adding SLS
(SODIUM LAURYL SULFATE).
3.simvastatin can be analysied by UV spectrophotometer at 237nm by
dissolving in acetonitrile.
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)