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The following message was posted to: PharmPK
In Drug Discovery group, we perform a combination of in vitro clearance
studies in microsome/S9/hepatocyte systems in multiple species
(including human) and in vivo studies in selected animal species before
choosing the optimal animal species for in vivo PK screening. (for
details, please see the recent publication: Balani et al. Current Topics
in Medicinal Chemistry (2005) 5: 1033-1038)
There is a suggestion (recently floated) to perform in vivo beagle dog
PK early on before dropping molecules (any chemical matter). I would
like to know your expert opinion on this. In my view, a particular
species may be an outlier for PK screening for a given chemical series
(eg. If there is species specific disposition). Without knowing the
appropriateness of beagle dog PK for a given chemical series, I would be
hesitant in performing screening in this species.
Thanks in advance
Raj Nagaraja, Ph.D.
Drug Safety and Disposition, DMPK
Millennium Pharmaceuticals, Inc.
45 Sidney St.
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