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Dear Group,
I'm posting this question to understand the
methods that are in use to assess the quantitative structure-
pharmacokinetic relationship (SPR) based on the molecular or
structural descriptors. In my experience, the most common approach is
collecting PK parameters from experimental data and correlating them
with the substitutes or side chains of the molecule if it is an
analog.Of course this would be a time consuming process since library
of compounds to be studied in any chemical class to understand it
better.
I would highly appreciate if anyone who is well versed with SPR can
explain the simple model that can effectively predict the PK
parameters in relation to structure. Also it would be of great help
if anyone who is exposed in SPR can share his views and thoughts.
Regards,
Syed Mustafa,
Dept of Pharmacokinetics and Metabolism,
Orchid RND centre,
Plot No:476/14,
Old Mahabalipuram Road,
Sholinganallur,
Chennai: 600119
syedmustafa.-a-.orchidpharma.com
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