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The following message was posted to: PharmPK
Dear All:
I am a tenderfoot on building PBPK model. I am now using
acslXtreme to build my
own model. I have a big problem that i don't know how to measure
tissue:blood
partition coefficient. I tried to find some document about this in
the library but
found nothing. Could anyone help me?
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Partition coefficient determination for non-volatile and intermediate
volatility chemicals in biological tissues. Jepson GW, Hoover DK,
Black RK, McCafferty JD, Mahle DA, Gearhart JM. Toxicologist 12:262
(1992)
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The following message was posted to: PharmPK
There are several and classical approaches for the estimation "in
vitro" or "in vivo" of the tissue/blood partition coefficient.
Chen, HSG., Gross, JF. J. Pharmacokin. Biopharm. 7: 117 (1979).
Lam, G., Chen, ML., Chiou, WL. J. Pharm. Sci. 71: 454 (1982).
Gallo, JM., Lam, FC, Perrier, DG. J. Pharmacokin. Biopharm. 15: 271
(1987).
In my own experience the best way to estimate the partition
coefficient, assuming linear pharmacokinetics, is by means of a
parametric approach of the Unit Disposition Function (UDF) of the
drug in the tissue using deconvolution between tissue and plasma levels.
Verotta, D., Sheiner, LB, Ebling, WF, Stanski, DR. J. Pharmacokin.
Biopharm. 17:463 (1989).
Ebling, WF., Wada, DR., Stanski, DR. J. Pharmacokin. Biopharm. 22:259
(1994).
Regards,
Prof. Jose M. Lanao
Dpt. Pharmacy and Pharmaceutical Technology
Faculty of Pharmacy
University of Salamanca
Spain
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)