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I'm wondering if there is any data on Tween 80 in mice. We have a
formuation that contains 40% Tween 80, but we must use mice as the
rodent model. The formulation would be IP and be administered for 7
days and 28 days. I found LD50 data for IP admin but nothing else.
Can anyone enlighten me on this subject?
Karen
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Dear Karen,
helpful reference might be:
Polysorbate 80: pharmacological study
Varma RK ; Kaushal R ; Junnarkar AY ; Thomas GP ; Shridhar DR ; et al
Arzneim. Forsch.; VOL 35 ISS 5 1985, P804-808
Best Regards
Stefano Porzio
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The following message was posted to: PharmPK
Dear Karen,
Two references that may be of use to you:
Varma, RK., et al. 1985. Polysorbate 80: A pharmacological study.
Arzneim.-Forsch. 35(5): 804-808
Final Report on the safety assessment of polysorbates 20, 21, 40, 60,
61, 65, 80, 81 and 85. J of the American College of Toxicology.
3(5):1-82.
Good luck,
Shawna
Shawna Fleming-Weis, Ph.D.
Drug Safety Assessment
Synta Pharmaceuticals Corp.
Lexington, MA 02421
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