Back to the Top
Dear all
I am going to do 4x4 crossover design with following sequences
RTRT
TRTR
RRTT
TTRR
for statistical anlysis of replicated design we use PROC MIXED in SAS
I am very confused to use it
how to calculated 90% Confidance Interval in such design
and interpretation of this design
I am Eagrly waiting for responce
Thanks in advance
Yogesh
+91 9867158389
Back to the Top
Suggest you look at FDA Guidance from Jan 2001 "Statistical
Approaches to Establishing Bioequivalence"
The SAS code you are interested in for average BE using replicated
data is in this document. Although the FDA suggests using 2 sequences
instead of 4.
mike
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)