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The following message was posted to: PharmPK
Can anyone suggest some good reviews or papers that discuss the
extraction and clean up of compounds from different biological
matrices? I am especially interested in extraction and cleanup of
stool extracts for metabolite profiling. I will be using UV
detection, so any papers that address removing matrix interferences
from stool extracts for UV detection would also be most helpful.
Brian Faulkner
Senior Scientist
Vitalea Science, Inc
phone: 530.669.1457
FAX 530.669.1457
www.vitaleascience.com
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This paper should be beneficial.
Sparreboom A, Huizing MT, Boesen JJ, Nooijen WJ, van Tellingen O,
Beijnen
JH. Isolation, purification, and biological activity of mono- and
dihydroxylated
paclitaxel metabolites from human feces.
Cancer Chemother Pharmacol. 1995;36(4):299-304.
Murad Melehm, Ph.D.
PK/PD Scientist
Cognigen Corporation
Buffalo, NY
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)