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Dear Members,
We working on a compound that has to get administered as a gavage to
rats for a 7 day tox study.pH of the dosing solution is 2.8 and we
are are giving at a rate of 10 ml/kg.The compound is dissolved in
propylene glycol(40):Water(50):Ethanol(10).Have anyone had experience
dosing rats with high acidic solutions.I have heard about bloating
and abdmonial pain that rats develop when they are gavaged with
acidic solutions. Is there any safety guidelines with respect to pH
of dosing solutions for gavage?
Thanks in advance,
John
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The following message was posted to: PharmPK
Typically, the pH limit for a solution to be administered by oral gavage
is 4. The repeated administration of a solution with a pH of 2.8
will/should be an (IACUC) issue.
Sincerely,
Joe
--
Joseph V. Rutkowski, PhD, DABT
Sr. Director
Preclinical Pharmacology and Toxicology
Predix Pharmaceuticals
4 Maguire Road
Lexington, MA 02421
T: 781-372-3260 ext. 1078
F: 781-372-3267
jrutkowski.aaa.predixpharm.com
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The following message was posted to: PharmPK
Dear John,
I don't understand why you should worry so much about pH when
stomach pH is reported to be very acidic and you deliver drug
directly in the stomach with the help of gavage. We have used this
method for delivering pH 3 solution to rats consecutively for 50
days. They were hale and hearty. So go ahead
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