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Dear colleagues,
What is the implication of genotyping and/or phenotyping in
bioequivalence studies? Is genotyping and/or phenotyping of subjects
necessary in single-dose cross-over bioequivalence studies, i.e.
metoprolol tartrate?
Thanks for your insights.
Joy
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Joy,
Genotyoing and Phenotyping is not required when you are carying out
BE study by cross over design, but definately to be considered when
it is a parallel design.
Some times to anticipate the metabolism and excretion it is to be
consideredlike.. slow acetylators, slow catalysers.
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)