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Dear colleagues, any one aware related to dissolution and estimation
of Glimepiride when it is in combination with Metformin. In-vitro
dissolution I am taking in 0.1N HCl.
Problem is that the glimepiride is poorly soluble drug in water and
less soluble even in buffer pH-6.8 and for estimation it by UV
spectrophotometer it is difficult to set method.
May I go for pH up to 7.4 then it may problematic to measure
metformin as per pharmacopoeia.
Please send your suggestio n what to do?
Thanks, in advance
With warm regards,
Bhadani Manish N.
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