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dear all
Gut metabolism how we can perform by in-vitro. is there any
possibilities do such kind of work in lab. please explain.
A.karthik
DMPK LAB,DISCOVERY RESEARCH
DR REDDYS LABORATORIES LTD
MIYAPUR
HYDERABAD
500049.
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Dear Karthik,
You can study gut metabolism using either everted gut sac or side-by-
side diffusion chamber (Ussing chamber) models. While both these
models allow study of reginal differences in metabolism, the later
has the additional advantge of studying transepithelial transport
along with gut metabolism. In situ itestinal perfusion model is also
widely used for this purpose.
Kasiram.
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The following message was posted to: PharmPK
Hello Karthik,
You can perform in vitro gut metabolism studies using intestinal S9.
Sandeep
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The following message was posted to: PharmPK
Does anyone know of a commercial source of rat intestinal S9 or
intestinal
microsomes? Thanks.
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