Back to the Top
The following message was posted to: PharmPK
Hi, everyone,
I met a surprise problem:
When I read some articles, I found someone use the methods which
process the time-concentration data in blood to deal with the data in
tissue,and drew a conclusion as "the drug fits first order absorption
and single compartment model",
I really do not understand why he could get this kind of conclusion,
I think there are a lot of differences between blood and tissues,and
the course of disposition must be different, so
why they use the same way process blood data to compute the
pharmacokinetic parameters of tissues with tissues data?
Would you like share your opinion with me/us?
Thanks in advance.
Jiang
--
Jiang zhigang
jiangzhigangchn.-a-.hotmail.com
Back to the Top
Dear Jiang Zhigang,
There is many physiological, chemical or phys chemical difference
between blood and tissues. It is good to establish rational methods
to deal with data. But one compartment model and two compartment
model are simple methods to describe the elimation and dispostion.
one compartment
---central compartment----
____blood or tissue
one compartment absortion
---absorption comparment---central compartment----
___________________________blood________
__central compartment____tissue compartment___
____blood__________________tissue_________
There are some differences, but the mathematical expressions are
similar.
If it is one compartment, or one absorption compartment model,
noncompartment methods could provide more stable results.
Ma Guangli
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)