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Dear Colleagues
I am looking for a list of publication, or something like that, with
values of intrinsic in vitro clearance of drugs calculate in
microsomes
and hepatocites. Thanks in anticipate for any help.
Best regards
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Dear Benjmin
Please go through the following article. Paper describes intrinsic in
vitro clearance of drugs calculate in microsomes. Plese let me know
if you can't get this article
The Prediction of Human Pharmacokinetic Parameters from Preclinical
and In Vitro Metabolism Data
R. SCOTT OBACH, JAMES G. BAXTER, THEODORE E. LISTON, B. MICHAEL
SILBER, BARRY C. JONES,
FIONA MACINTYRE, DAVID J. RANCE and PHILIP WASTALL
Departments of Drug Metabolism, Pfizer Central Research, Groton,
Connecticut (R.S.O., J.G.B., T.E.L., B.M.S.), and Sandwich, Kent
(B.C.J., F.M., D.J.R., P.W.), UK
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Vol. 283,
No. 1
JPET 283:46-58, 1997
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)