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Dear all,
I am wondering how can I calculate the infusion dose to acheive a
specific AUC? In other words, I have a known AUC but I know to know
the infusion dose to achieve this.
The caculation will be based on single compartment with known Vd, k,
and a specified infusion period.
Thanks in advance.
Eric Siu
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The following message was posted to: PharmPK
If you know Vd and k you can calculate Clearance=Vd*k
Dose=AUC*Clearance
The infusion duration does not make any difference to the AUC. Its up
to you to pick an infusion duration that you think will be safe.
You don't say over what interval you want the AUC but I am assuming
you mean the target AUC is over a dosing interval at steady state or
the AUC from 0 to infinity after a single dose.
IMHO it is clearer to think about a target concentration (TC). Then
you can calculate the dose rate from Clearance*TC. This would be the
continous infusion rate to maintain the TC.
You can also calculate the loading dose from Vd*TC. Thinking about
the initial TC is important when you need to specify the infusion
duration.
--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New
Zealand
email:n.holford.aaa.auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556
http://www.health.auckland.ac.nz/pharmacology/staff/nholford/
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