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Dear all,
Does anyone have a LC-MS-MS method for atazanavir assay in human plasma?
Thanks in advance.
Dr. Laure Monlauzeur
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Here are the reference for the assay
J. Chromatog. B 788 (2003), 377
J. Chromatog. B 795 (2003) 273-289
Satish Rao
Scios, Inc.
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The following message was posted to: PharmPK
Several grops have described LC-MS/MS methods for plasma and
cell-associated (intracellular) atazanavir concentrations including:
Dickinson L, Robinson L, Tjia J, Khoo S, Back D. Simultaneous
determination of HIV protease inhibitors amprenavir, atazanavir,
indinavir, lopinavir, nelfinavir, ritonavir and saquinavir in human
plasma by high-performance liquid chromatography-tandem mass
spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Dec
27;829(1-2):82-90.
Koal T, Burhenne H, Romling R, Svoboda M, Resch K, Kaever V.
Quantification of antiretroviral drugs in dried blood spot samples by
means of liquid chromatography/tandem mass spectrometry. Rapid Commun
Mass Spectrom. 2005;19(21):2995-3001.
Crommentuyn KM, Rosing H, Hillebrand MJ, Huitema AD, Beijnen JH.
Simultaneous quantification of the new HIV protease inhibitors
atazanavir and tipranavir in human plasma by high-performance liquid
chromatography coupled with electrospray ionization tandem mass
spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 May
25;804(2):359-67.
Colombo S, Beguin A, Telenti A, Biollaz J, Buclin T, Rochat B,
Decosterd LA. Intracellular measurements of anti-HIV drugs indinavir,
amprenavir, saquinavir, ritonavir, nelfinavir, lopinavir, atazanavir,
efavirenz and nevirapine in peripheral blood mononuclear cells by
liquid chromatography coupled to tandem mass spectrometry. J
Chromatogr B Analyt Technol Biomed Life Sci. 2005 May
25;819(2):259-76.
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The following message was posted to: PharmPK
Hello,
Wanted to know if any work has been carried out regarding in vivo
studies to monitor concentration of drug / metabolites in blood
(urine ?) and methods of using these to infer PK parameters (overall
or tissue / specific) ?
Regards,
Sundar
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