# PharmPK Discussion - Least Square Mean

PharmPK Discussion List Archive Index page
• On 1 May 2006 at 06:16:32, shekar (shekar_stats.-at-.yahoo.co.in) sent the message
`Dear all..             I will be happy, if anyone could clarify my doubt.             We are using  "least square means" in bioequivelencestudies.             I observed  that Arithmetic means and least square meansare equal.             What is relation between these two?             What is the formula for calculating LSM?Regards,Shekar.`
Back to the Top

• On 2 May 2006 at 11:12:01, "sulagna" (sulagna.das.at.veedacr.com) sent the message
`The following message was posted to: PharmPKHi,For computing Arithmatic mean we consider the frequencies or weights.While for computing Least square mean the frequencies are notconsidered. They are assumed to be equal.     Hence when the frequencies are same AM=LSM.  So in case of abalanceddesign when the number of sequences are same  AM = LSMRegardsSulagna`
Back to the Top

• On 3 May 2006 at 05:19:14, shekar (shekar_stats.-a-.yahoo.co.in) sent the message
`Hi..        Sulagna       Iam sorry to say that , Iam a bit confused with your answer.       Could you please explain your answer with bioequivalence example.Regards,shekar.`
Back to the Top

• On 3 May 2006 at 10:21:17, Sulagna das (sd_075.aaa.yahoo.com) sent the message
`ok,Formula for AM            n(A) + m(B)  :  Where n and m arefrequencies of A and B                           ----------                               n+mFormula for LSM              A + B  :  Because in LM the frequenciesare not considered                              -----                                2Therefore when n is equal to m then AM is  A + B     which is alsothe LSM                                            ----                                              2Hence for balanced designs where number of subjects in  bothsequences are same, the AM is equal to LSMI hope I am clear now .......Sulagna`
Back to the Top

Want to post a follow-up message on this topic? If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Least Square Mean" as the subject

Copyright 1995-2010 David W. A. Bourne (david@boomer.org)