- On 1 May 2006 at 06:16:32, shekar (shekar_stats.-at-.yahoo.co.in) sent the message

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Dear all..

I will be happy, if anyone could clarify my doubt.

We are using "least square means" in bioequivelence

studies.

I observed that Arithmetic means and least square means

are equal.

What is relation between these two?

What is the formula for calculating LSM?

Regards,

Shekar. - On 2 May 2006 at 11:12:01, "sulagna" (sulagna.das.at.veedacr.com) sent the message

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The following message was posted to: PharmPK

Hi,

For computing Arithmatic mean we consider the frequencies or weights.

While for computing Least square mean the frequencies are not

considered. They are assumed to be equal.

Hence when the frequencies are same AM=LSM. So in case of a

balanced

design when the number of sequences are same AM = LSM

Regards

Sulagna - On 3 May 2006 at 05:19:14, shekar (shekar_stats.-a-.yahoo.co.in) sent the message

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Hi..

Sulagna

Iam sorry to say that , Iam a bit confused with your answer.

Could you please explain your answer with bioequivalence example.

Regards,

shekar. - On 3 May 2006 at 10:21:17, Sulagna das (sd_075.aaa.yahoo.com) sent the message

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ok,

Formula for AM n(A) + m(B) : Where n and m are

frequencies of A and B

----------

n+m

Formula for LSM A + B : Because in LM the frequencies

are not considered

-----

2

Therefore when n is equal to m then AM is A + B which is also

the LSM

----

2

Hence for balanced designs where number of subjects in both

sequences are same, the AM is equal to LSM

I hope I am clear now .......

Sulagna

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