PharmPK Discussion - Linezolid and Rifampin Interaction

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On 1 Aug 2006 at 16:29:32, David Bourne (david.-at-.boomer.org) sent the message


Is there any information on drug-drug interactions between linezolid
and rifampin??
Are there any known metabolic interactions (P450s)
Lastly, any information for either on effects on P-gp transport
(substrate/inhibitors/inducer)
Thanks Dave

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On 1 Aug 2006 at 08:09:11, Carol Collins (collinsmd.at.earthlink.net) sent the message


Dave:

Please see Clin Pharmacol Ther. 2005 May;77(5):451-3.
Linezolid and rifampin: Drug interaction contrary to expectations?
Egle H, Trittler R, Kummerer K, Lemmen SW.
PMID: 15900290 [PubMed - indexed for MEDLINE]
The authors of this paper suggest that linezolid is a substrate of Pgp.

Carol Collins MD
University of Washington Metabolism and Transport Drug Interaction
Database

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