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This is with reference to your message PharmPK Discussion - Low
bioavailability drugs list on http://www.boomer.org/pkin/PK99/
PK1999132.html . I would like to know the reason for low
bioavailability of ganciclovir. If you have any idea or any ref link
please let me know
with regards
--
Shamsunder Dodiya
Ph.D. Research Scholar,
NDDS Research Lab,
G.H.Patel centre for postgraduate studies & centre,
Opp.University Main office,
The M.S.University of Baroda,
Donors Plaza,
Vadodara-390002 .Guj.India
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The following message was posted to: PharmPK
Low bioavailability of ganciclovir may be due to its lipophilicity
(octanol:water partition co-efficient of 0.022) although others have
speculated it is due to solubility. See Norris DA, et al.
Development of predictive pharmacokinetic simulation models for drug
discovery. Journal of Controlled Release 65 (2000) 55-62
Regards,
Thomas Kakuda, Pharm.D.
Director, Clinical Pharmacology
Tibotec, Inc.
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)