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The following message was posted to: PharmPK
Please note that the MDRD equation estimates GFR, while the other
equations being discussed (Cockcroft & Gault, Jelliffe & Jelliffe)
estimate CrCl. These, obviously, are related values, but not
identical or interchangeable.
Additionally, the 2 CrCl methods have stood the test of time so
investigators and clinicians understand the strengths and weaknesses
of both due to extensive publication of peer-reviewed studies. MDRD
is the new kid on the block and still needs broad, independent
validation in patient subpopulations by investigators outside the
innovator group.
--Larry
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)