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The following message was posted to: PharmPK
After much thought, I would be interested to hear you opinions on the
derivation of a MM-type enzyme process, but without using the
traditional Vmax or Km, for pathways such as transport?
With regards
R.Badhan
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Hi Raj,
I may be missing the point, but surely the constants Vmax and Km are
integral to describing any M-M process.
- Peter
Peter W. Mullen, PhD, FCSFS
KEMIC BIORESEARCH
Kentville
Nova Scotia, B4N 4H8
Canada
Tel. (902) 678-8195 Fax (902) 678-2839 E-mail pmullen.-at-.kemic.com
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The following message was posted to: PharmPK
Dear Dr. Badhan,
Please keep in mind that the Michaelis-Menten equation has a (strong)
theoretical background. If you like to use another equation, I would
recommend picking one which also has a theoretical background.
There are other parameterizations of the Michaelis-Menten equation,
which you could use. (I am not sure, if you meant those.)
Mathematically, the Michaelis-Menten equation has the same form as
the Langmuir isotherm in physical chemistry. There is several other
isotherms (e.g. the Freundlich isotherm) which have been developed
in physical chemistry and which have a theoretical basis. However,
I am not sure, if their theoretical background is applicable to PK.
When you define your objectives more specifically, it would be easier
to give you a recommendation. Hope it helps.
Best regards
Juergen
--
Juergen Bulitta, PhD, Post-doctoral Fellow
Pharmacometrics, University at Buffalo, NY, USA
Phone: +1 716 645 2855 ext. 281, j.-at-.bulitta.com
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