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I face with the problem of how to calculate the mean residence time
(MRT) from Conc vs time data. No problem for the parent drug where
MRT corrected for time infusion = AUMCt/AUCt -T (IV)/2. The problem
arise when I want also consider the metabolites species in which the
parent drug is transformed.
Which approach I should adopt to calculate the MRT for the
metabolites? Moreover , it is appropriate to calculate the volume
Vdss as following: Vdss= Clearance *MRT for both parent drug and
metabolites. What is the meaning of Vdss so calculated.?
The pharmacokinetic of parent drug and metabolites are following a
multicompartment model , however I would like analysis the PK trough
non-compartmental analysis, this way all my questions about MRTs.
Anybody can help me ??
Many thank in advance for you help
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