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The following message was posted to: PharmPK
We are exploring maturation of aminoglycoside clearance with age in
neonates/children and trying to disentangle development from size
order to investigate maturation we would like to compile a large data
looking at renal function with age.
We already have quite a lot of data describing aminoglycoside total
from which we have tried to deduce renal function but it would be
satisfying to get some actual measurents of renal clearance --
inulin, drugs -- and/or measurements of GFR.
We have located a large data set in the literature but unfortunately the
authors, though willing, are unable to find the numbers again. So we are
starting over again and seeking help from anyone who would like to
their data, no matter who small the numbers, that would let us build
keep building) a data set that can be used to describe the maturation of
renal function as well as the changes with body size.
If you are interested in helping us by adding your own data to a pool we
would be very grateful if you would contact us to discuss how to do
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New
email:n.holford.at.auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556
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