- On 21 Apr 2006 at 14:57:01, "Raj Badhan" (R.K.Badhan.at.manchester.ac.uk) sent the message

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The following message was posted to: PharmPK

Dear All,

I'm currently predicting oral absorption through compartmental

modelling.

I'm trying to find details of the microscopic rate constants for as

many drugs as I can.

I know this is a commonly asked question, but it would save me hours

and days of searching if someone can point me

in the right direction for some values of the microscopic rate

constants (k12,k21 etc etc along with compartment volumes for the PK

compartments).

I have some, but it's a hard job trying to find such data in the lit.

so any help would be appreciated!

Raj Kumar Badhan - On 21 Apr 2006 at 14:29:17, "Shawn D. Spencer" (shawn.spencer.-at-.famu.edu) sent the message

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Hello Raj,

If I understand your needs correctly, it is not likely that anyone

has compiled a database of compartment microconstants for a large

number drugs. Even if someone has done so, correlating this info

with molecular structure/size, lipophilicity parameters etc. is quite

an endeavor.

If you offer some more insight into your data mining efforts (i.e.,

what you mean by "you are predicting oral absorption"), we might be

able to help.

Cheers,

Shawn D. Spencer, Ph.D., R.Ph.

Assistant Professor of Biopharmaceutics and Pharmacokinetics

College of Pharmacy and Pharmaceutical Sciences

Florida A&M University

Tallahassee, FL 32311

shawn.spencer.aaa.famu.edu - On 22 Apr 2006 at 09:03:47, "Ma Guangli" (guanglima.-at-.gmail.com) sent the message

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Dear Raj Kumar Badhan,

I am doing some work on ADME in silico. Maybe, you want to

predict these constant using QSPR. I found there are 300 drugs PK

parameters in a PK & biopharmaceutics book. But the book is in

Chinese.You can try the pharmacokinetics & biopharmaceutics book to

find what you want.

I do not find such a database.

Ma Guangli

Ph.d. Candidate - On 24 Apr 2006 at 10:53:29, Jagannath Kota (Jagannath.Kota.aaa.vcp.monash.edu.au) sent the message

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The following message was posted to: PharmPK

Dear Raj,

Your question is interesting as I havn't heard of some values for micro

constants. Could you please be clearer?

Well if you are talking of giving an initial estimate for micro

constants to the model for fitting your data, then you may have to do it

by curve stripping etc. I give an initial estimate for volume from my

data (Dose/Co from IV data).

I guess the group can help if you are clearer with your question,

cheers,

Jagannath - On 21 Jul 2006 at 11:26:26, "sushil kale" (kalesushil.-at-.rediffmail.com) sent the message

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Res Sir/Madam;

here im sending a basic query on calculating the pharmacokinetic

parameter in bioequivalence study.

first know about all parameters 1)Cmax 2)Tmax 3)AUCo-t 4)AUCo-inf 5)

Kele 6)t1/2

i want to solve Kele means elimination rate constant.or in detail

Kele-Appear first-order elimination or terminal rate constant

calculated from semi-log plot of the plasma concentration versus time

curve.the parameter is calculated by the linear least square

regression analysis using the three (or more) non zero plasma

concentration.

formula for Kele=(LnC1 - LnC2)/T2-T1

where C1 & C2 are first & last nonzero concentration point in

elimination phase.and T1&T2 are respective time point of C1& C2.

Q1.How can we consider exact C1 & C2?

Q2.What is the detailed procedure for calculation of Kele?

Q3.What is the linear least square regression analysis method? i want

this method with example.

please guide me.

thank you

sushil kale

[Have a look at http://www.boomer.org/c/p4/ chapter 4 for info about

the calculation of kel. http://www.boomer.org/c/p3/ has some

information about non linear regression in a number of chapters - db]

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