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The following message was posted to: PharmPK
Dear all,
Could anybody give information about the pKa of primidone.
Thanks
Dr Khaldoun Al-sou'od
Assitant Professor of Physical Chemistry
Department of Chemistry
Al al-Bayt University
Mafraq 25113
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The following message was posted to: PharmPK
Khaldoun
In 'Drug Monitoring and Pharmacokinetic data' by Pribor HC, Morrell G
and Scherr GH (1980), there's a reference to Newton DW and Kluza RB,
"pKa values of Medicinal Compounds in Pharmacy Practice", Drug Int.
and Clin.Pharm. 12:Sept, 1978, mentioning the pKa of primidone as >13.
Hope it helps.
Luis
--
Luis M. Pereira, Ph.D.
Assistant Professor, Biopharmaceutics and Pharmacokinetics
Massachusetts College of Pharmacy and Health Sciences
179 Longwood Ave, Boston, MA 02115
Phone: (617) 732-2905
Fax: (617) 732-2228
Luis.Pereira.aaa.bos.mcphs.edu
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