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When comparing the biopharmaceutical performance of different dosage
the selection of an animal model is an important issue as all animals
their pros and cons. We have presently selected the rabbit, because
ease of drug administration and blood sampling (ear). Unfortunately, we
observe a rather high variability and an erratic concentration-time
for the dosage form of a low solubility compound (administered in a
capsule). We would welcome any suggestions with respect to the following
-How to handle coprophagy?
-When using oral gavage, how much volume should be given? Could a
of pH 2 be used?
-Should the rabbits have access to food and water immediately after drug
-Is overnight fast before drug administration required?
-How long could a rabbit be kept in a restraining box?
-Has the position of the rabbit in this restraining box an influence
motility of the GI tract?
Laboratorium voor Farmacotechnologie en Biofarmacie
O&N II Gasthuisberg Bus 921
3000 Leuven Belgium
Tel 016-330.301 Fax 016-330.305
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