Back to the Top
The following message was posted to: PharmPK
Dear Colleagues,
Do you include time zero (pre-dose)
conc for calculation of AUC on the last day of repeated iv
administration?
Rostam
[Use Cp's from the start of the last interval (trough) through Cp's
up to the time of the next interval, if another dose was to be given.
See Figure 15.4.1 Plot of Cp versus Time after Multiple Oral
Administration showing AUC at Steady State on http://www.boomer.org/c/
p4/c15/c1504.html For IV you might extrapolate back to t, start of
interval, as you would for a first dose AUC - db]
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)