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I am working with a monoclonal that forms anti-antibodies to it
during therapy. The titers are about 50000 at the end of therapy.
Two months after the end of therapy, titers drop to < 444, the BQL of
the assay. Has anyone seen this with any other biologics? Is this
normal?
Thanks,
Pete Bonate
Peter L. Bonate, PhD
Genzyme Corporation
Director, Pharmacokinetics
4545 Horizon Hill Blvd
San Antonio, TX 78229 USA
peter.bonate.aaa.genzyme.com
phone: 210-949-8662
fax: 210-949-8219
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