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Dear Thomas,
There is a possibility that a drug is eliminated mostly by the routes
other than liver and kidney. You might be interested in the following
article
A convenient method for estimating the quantity of drug eliminated by
the routes other than hepatic metabolism and renal excretion and the
fraction of drug that reaches the "first pass" after oral
administration. J. Pharm. Sci. 2006, v.95(4), 828-833.
Best regards,
Leo Berezhkovskiy
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)