PharmPK Discussion - Acceptable IV vehicle for reproductive studies

• On 8 Feb 2007 at 05:12:27, "Sree Bhat" (sbhat.-at-.celgene.com) sent the message
  

  
  Dear Friends,
  We are working on a formulation development of a new compound in an
  IV dosage form to contain ~ 50 mg/ml to perform toxicology studies in
  pregnant Rabbits. The problem we are facing is that the compound has
  very minimum or no bioavailability orally and we have to go IV or SC
  route preferably IV. Since we can not use some of the common vehicles
  for IV route such as ethanol, DMSO or DMAC because these vehicles
  have an impact on pregnancy themselves, we are limited to very few
  solvents. I would appreciate it if you can help me find an acceptable
  solvent/vehicle for reproductive studies in Rabbits via IV route.
  The compound is neutral.
  Thanks in advance.
  Sreenivas Bhat
  Associate Director, Pharmaceutical Technology
  Celgene Corporation
  86 Morris Avenue
  Summit, NJ 08852
  E-mail: sbhat.aaa.celgene.com
  
  

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