PharmPK Discussion - Bioavailability of chymotripsin

• On 18 Sep 2007 at 08:27:13, mohammed muhiyideen (mmuhiyideen.-a-.yahoo.com) sent the message
  

  
  Dear friends,
  
  We would like to do a bioavailability study of chymotripsin. Because
  it is an enzyme present naturaly in our digestive system we face
  difficulties in designing the study.
  what is meant by armor unit in which chymotipsin is represented?
  please give your valuable inputs
  
  with thanx and regards,
  muhiyideen
  Chennai.
  
  

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• On 20 Sep 2007 at 11:19:37, "Peggins, James (NIH/NCI) [E]" (pegginsj.aaa.mail.nih.gov) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hi,
  
  For the definition of Armour Unit see:
  
  http://www.biochemj.org/bj/066/0342/0660342.pdf
  
  The Effects of Proteolytic Enzymes on the Hyaluronic
  Acid Complex of Ox Synovial Fluid
  By B. S. BLOOMBERG* AND A. G. GORTON
  Department of Biochemistry, University of Oxford
  
  One Armour unit, assayed by the method of Anson (1938), gives in 10
  min. at 25C, colour equivalent to 1 ug. of tyrosine.
  
  As to the question of the bioavailability of chymotrypsin, there is a
  1963 paper in Nature
  
  http://www.nature.com/nature/journal/v199/n4895/abs/199815a0.html
  that might be relevant.
  
  Regards,
  
  Jim Peggins
  
  

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