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Dear All,
I have some confusion around calculation of clearance in WinNonlin.
In model 11, first order absorption, two compartment,no lag time, if
we parameterize by clearance, the equation shows clerance=V1*K10.
However, the calculated clearance matches the one calculated with NCA
model for extravascular input. My question is:
Is beta used in actual calculation? Because in two compartment
model, beta equals LZ so clearance calculated as D/AUC equals V*lz.
But, if we use V*K10 then the clearance from compartment model should
be much lower than NCA.
I appreciate your clarifications.
Sincerely,
Ayyappa Chaturvedula
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The following message was posted to: PharmPK
Dear Ayyappa,
The equations you mentioned should give the same (correct)
value for clearance (or better: CL/F in case of
extravascular dosing):
- V1*K10
- D/AUC
- V*lz
Depending on the method (compartmental or NCA), the value
may differ slightly.
However, using V*K10 will give something different, and is
certainly incorrect.
Best regards,
Hans Proost
Johannes H. Proost
Dept. of Pharmacokinetics and Drug Delivery
University Centre for Pharmacy
Antonius Deusinglaan 1
9713 AV Groningen, The Netherlands
Email: j.h.proost.-at-.rug.nl
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