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Dear All,
Can anybody comment on the phenomenon of delayed Tmax after IV
infusion longer than the Infusion period?
Thanks in advance.
-Ayyappa Chaturvedula
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The following message was posted to: PharmPK
Ayyappa,
The drug precipitation in the vein may be on easy cause for this
event. You may find the following reference useful.
Correlation of delayed peak concentration with infusion-site
irritation following diazepam administration.DICP. 1990
Jul-Aug;24(7-8):678-81.
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The following message was posted to: PharmPK
Dear Ayyappa,
You asked:
Can anybody comment on the phenomenon of delayed Tmax after IV
infusion longer than the Infusion period?
Secondary peaks after intravenous administration have been observed for
temoporfin (Foscan) which have been related to binding to blood
components.
See: Glanzmann et al. Photochem Photobiol 1998 67 :596602
And Hopkinson et al Photochem Photobiol 1999 69 :482-8
Regards,
Charlie
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