PharmPK Discussion - Dissolution of oxcarbamazepine

• On 19 Feb 2007 at 03:25:42, Mr payam seyfi (paseyfi.aaa.yahoo.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Please, I need to know the method of the dissolution test of
  oxcarbamazepine (tablet).Best regards,
  P. Seyfi
  
  

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• On 23 Feb 2007 at 10:39:33, Tzviel Sheskin (tsheskin.-at-.netvision.net.il) sent the message
  

  
  Dear Mr Seyfi,
  You can get the dissolution requirements for Oxcarbazepine Tablets
  for the
  FDA website:
  http://www.accessdata.fda.gov/scripts/cder/dissolution/index.cfm?c=1
  For each Oxcarbazepine strength, there is a slight difference in the
  medium
  for the dissolution.
  Oxcarbazepine (150 mg) Tablet, Paddle, 60 RPM, Medium: 0.3% SDS in
  water,
  900 ml, Sampling time: 10, 20, 30, 45, 60 and 90.
  Oxcarbazepine (300 mg) Tablet, Paddle, 60 RPM, Medium: 0.6% SDS in
  water,
  900 ml, Sampling time: 10, 20, 30, 45, 60 and 90.
  Oxcarbazepine (600 mg) Tablet, Paddle, 60 RPM, Medium: 1% SDS in
  water, 900
  ml, Sampling time: 10, 20, 30, 45, 60 and 90.
  Hope this helps,
  T Sheskin
  
  

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