PharmPK Discussion - Dosing interval - lost dose

• On 19 Jun 2007 at 14:22:51, "Koren, Lidija" (Lidija.Koren.at.pliva.hr) sent the message
  

  
  Hi  everybody,
  I was reading your disscusion and I would like from somebody to
  explain what does this dosing interval  really mean.
  If i have a study single dose cross over comparative and the product
  is modified release. Sampling is thru 72 hours and  washout period is
  7 days.
  Am i going to drop the data from pk/stat analysis if subject vomits
  thru 72 hour after dose or if subject vomits thru the hole study or I
  will use 2* median Tmax as a boundary for that?
  And I would be very happy if somebody could refer me to a good book,
  article, or anything useful.... where emesis, diarrhea, saline
  solution infusion and there impact on pk of drugs
  is explained.
  Thanx in advance,
  lidija
  
  

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• On 19 Jun 2007 at 21:22:10, "Hiren Mehta" (hirenpharm.-a-.gmail.com) sent the message
  

  
  Hi Lidija,
  For MR (ER or CR or EC) products dosing interval is generally 24 hrs.
  You can exclude if vomitting occurs during dosing interval, because
  we are not sure for MR products regarding the absorption length.
  Hope this helps.
  
  

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