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Dear All
We are working on nasal drug delivery system and pharmacokinetic in
rats. As drugs is practically insoluble in water irrespective of pH.
Can any one help us regarding selecting the vehicle for
pharmacokinetic study via nasal route.
I will be very thankful if any one will help in this regard.
PRASHANT
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The following message was posted to: PharmPK
Dear PRASHANT, regarding Nasal delivery and PK.
I suggest finding a co-solvent, and study it using nasal lavage of
rats. PEG, up to and including 3350, and PG ae often successfully
used. Other cosolvents can be used as well, but may not be lead to an
acceptable clinical formulation when the time comes.
Regards,
Frank
Frank Bales, Ph.D.
frankbales.aaa.msn.com
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The following message was posted to: PharmPK
Dear Prashant
Try to use cyclodextrins for the preparation of nasal solution.
For more information, the following reviews will be useful.
Merkus, F.W. et al: Cyclodextrins in nasal drug delivery, Adv. Drug
Deliv.
Rev. 1999, 36(1), p 41-57.
Marttin, E. et al: Efficacy, safety and mechanism of cyclodextrins as
absorption enhancers in nasal delivery of peptide and protein drugs,
J. of Drug Target. 1998, 6(1), p17-36.
Best regards, Maria Vikmon
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Look at some of the thixotropic formulations to assure dose
integrity, these can be administered as suspensions.
Sanjeev Thohan, PhD
Director, DMPK
Exelixis, Inc
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