PharmPK Discussion - Gavage Solution pH

• On 27 Jun 2007 at 13:28:28, "Laurie" (lcarpenter180.-a-.embarqmail.com) sent the message
  

  
  Dear members,
  I am a consultant who needs to find out if a gavage solution pH of
  10.1 is too high for a rat. We have tried diluting the solution to
  the maximum allowable volume and this does not lower the pH.  Should
  I be concerned enough to administer the material by another route (or
  in a different vehicle than water)?
  Regards,
  Laurie J. Carpenter
  180 Coralwood Dr.
  Kingsport, TN 37663
  
  

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• On 27 Jun 2007 at 14:31:11, "Rupesh Amin" (ramin.at.celgene.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Usually for Tox Study, I would prefer pH of 3-9. If you are dealing w/
  single dose PK, it should be fine. Can you try formulating in a
  different vehicle?
  
  Adjusting the pH of your formulation containing test article sounds like
  its challenging and you may want to be careful of the test article
  crashing out if you do adjust test-article containing formulation to an
  acceptable pH range. In general though, if your study is of longer
  duration, you may consider having your control vehicle pH adjusted to be
  comparable so as to at least have control data at higher pH.  If your
  study is a tox study, this will allow you to understand if any
  irritation/histo change are due to higher pH or a test-article related
  effect.
  
  Rupesh P. Amin, Ph.D.
  Senior Manager, Toxicology
  Early Drug Development,
  Celgene Corporation.
  86 Morris Avenue,
  Summit, NJ
  
  

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• On 27 Jun 2007 at 14:37:32, "Noha Salama" (nohasalama.-at-.gmail.com) sent the message
  

  
  hello
  this high PH will definately alter the acidic environment and as such
  any data on absorption may not be representative of the true values.
  Depending on the objectives of your study, I suggest you consider a
  buffer solution.
  Sincerely
  Noha
  
  

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• On 28 Jun 2007 at 00:34:15, "Ed O'Connor" (Ed.OConnor.at.tandemlabs.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  What are you gavaging? Small intestine?  If so that ought to work.
  STOMACH no!!!  LUNGS NO!!!
  
  Ed O'Connor, PhD
  Technical Director, Immunoanalytical
  Tandem Laboratories
  115 Silvia Street
  West Trenton, New Jersey
  609-228-0243
  ed.oconnor.aaa.tandemlabs.com
  
  

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