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Dear PharmPK Members,
I have two questions on GI motility in humans.
1. Is there sex difference in GI motility?
2. Do drugs acting on serotonin receptors have an effect on GI motility?
Any reference(s) will be helpful.
Thank you in advance.
Best regrads,
Raju
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The following message was posted to: PharmPK
Poola
To answer your first question on differences in gut motility between
the
sexes you do not find systematic differences when you actually measure
gastric or gut transit in healthy volunteers. However, lower gut
transit can
be altered during menstrual periods and more women than men suffer from
constipation and the IBS. Nausea and occasionally anorexia are
associated
with retarded gastric emptying and can also occur during menstruation.
On your second question, serotonin agonists certainly do affect gut
motility and to prove it there are literally thousands of references
since
for example, several 5-HT antagonists are now available as anti-
emetics or
treatment for the Irritable Bowel Syndrome. I suggest you do a web
search
on 5-HT, gut, receptors and you will get hundreds of references, such
as:
McLean PG, Borman RA, Lee K. 5-HT in the enteric nervous system: gut
function and neuropharmacology. Trends Neurosci. 2007 Jan;30(1):9-13.
That paper comes from the group at GSK Harlow that was led by Gareth
Sanger
so if you search on " Sanger GL Author" you will also get many
references
on the various agents that do affect gut motility. You will see that
it is
a bewildering world with peptides and hormones involved as well as
simpler
transmitters like serotonin.
Another useful and more recent reference is Costedio MM, Hyman N,
Mawe GM.
Dis Colon Rectum. 2007 Mar;50(3):376-88. Who write the following
introduction:
Serotonin (5-HT) is most commonly thought of as a neurotransmitter in
the
central nervous system. However, the predominant site of serotonin
synthesis, storage, and release is the enterochromaffin cells of the
intestinal mucosa. Within the intestinal mucosa, serotonin released
from EC
cells activates neural reflexes associated with intestinal secretion,
motility, and sensation. Two important receptors for serotonin that are
located in the neural circuitry of the intestines are the 5-HT(3) and
5-HT(4) receptors; these are the targets of drugs designed to treat
gastrointestinal disorders. 5-HT(3) receptor antagonists are used to
treat
nausea and emesis associated with chemotherapy and for functional
disorders
associated with diarrhea....
I hope this is what you were looking for.
Andrew Sutton
Guildford Clinical Pharmacology Ltd
URL: www.gcpl.co.uk
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The following message was posted to: PharmPK
Hello, I'm Francisco Fernandez, pharmacist and PhD student in PK.
About 1st question, I don't know, I'm think it's not, about the 2nd
yes, some drug like metoclopramide (5HT4 agonist), clebopride,
zinitapride accelerate the GI motility
best regards
fran
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