Back to the Top
Dear, any one aware related to dissolution and estimation
of Glimepiride when it is in combination with Metformin. In-vitro
dissolution I am taking in 0.1N HCl.
Problem is that the glimepiride is poorly soluble drug in water and
less soluble even in buffer pH-6.8 and for estimation it by UV
spectrophotometer it is difficult to set method.
May I go for pH up to 7.4 then it may problematic to measure
metformin as per pharmacopoeia.
Please send your suggestio n what to do?
Thanks, in advance
With warm regards,
Want to post a follow-up message on this topic?
If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Glimepiride invitro dissolution and estimation problem" as the subject
Support PharmPK by using the
Copyright 1995-2011 David W. A. Bourne (email@example.com)