PharmPK Discussion - IV infusion

• On 22 Mar 2007 at 14:26:17, (Jason.Jiang.-a-.sanofi-aventis.com) sent the message
  

  
  Hi All,
  We did a rat IV infusion study. The results were interesting and
  puzzling. We set up the infusion for 15 min. The vehicle is 60% PG
  and 3 % Dimethylacetamide in saline. Blood samples were taken at 5,
  10, and 15 min for the infusion phase. The plasma concentration was
  highest at 10 min instead of 15 min when the pump was stopped. The
  concentration at 15 min was about 50% less than that at 10 min. We
  double checked infusion pumps. Pumps seem accurate. The plasma
  concentration after 15 min seem good (like regular IV bolus). Did any
  body encountered the same situation before? How can I interpretate
  the data?
  Any suggestions will be greatly appreciated.
  Jason
  
  

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• On 22 Mar 2007 at 19:30:28, Gilberto De Nucci (denucci.at.gdenucci.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dear Jason
  
  Has the compound any pharmacodynamic effect in vivo that could affect
  the clearance?
  
  Best wishes,
  
  Gilberto
  
  

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• On 23 Mar 2007 at 10:42:52, "sankaratata" (sankaratata.aaa.indiatimes.com) sent the message
  

  
  Dear Jason,
  Have you taken the concn time profile for some more period. that
  would have given you a more detailed picture.
  I cannot conclude basing on the little info you have given. Does the
  drug has first pass effect. or  May be there is a rapid uptake by the
  followed by equilibration with the tissue compartments.
  There are many thought domains before a possible answer can be found.
  Regards,
  Santosh Tata
  Bioanalytical Division, BEC
  Apotex Inc, Bangalore
  
  

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