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Dear members,
We got LC-NMR system in our institute recently, and we are exploiting
the same for impurity profiling and characterization. Simultaneously,
we are also having our metabolite characterization lab here. We are
using LC-MSn and LC-MS-TOF for latter, however, LC-NMR is not being
used for metabolite research, because of the less sensitivity. I
would appreciate if you can suggest me what should be my strategy to
confirm the structure of the metabolites using LC-NMR and what is
real applicability of LC-NMR in metabolite research.
Sincere regards
Bhagwat Prasad
Doctoral Student
NIPER
INDIA
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Dear Bhagwat
You can refer following articles to design your strategies.
1.
Improving the decision-making process in the structural modification
of drug candidates: enhancing metabolic stability
Nassar, A.-E.F. / Kamel, A.M. / Clarimont, C. , Drug Discovery Today,
9 (23), p.1020-1028, Dec 2004
http://www.scirus.com/srsapp/sciruslink?src=sd&url=http%3A%2F%
2Fwww.sciencedirect.com%2Fscience%3F_ob%3DGatewayURL%26_origin%
3DScienceSearch%26_method%3DcitationSearch%26_piikey%
3DS1359644604032805%26_version%3D1%26_returnURL%3Dhttp%253A%252F%
252Fwww.scirus.com%252Fsrsapp%252Fsearch%253Fq%253D%2528LC-MS-NMR%
2529%252BAND%252B%2528issn%25253A13596446%2529%2526t%253Dall%2526ds%
253Dsd%2526drill%253Dno%2526p%253D0%26md5%
3De39433b99189a04b4cbc69c8fb3c62b6
2.
Strategies for dealing with metabolite elucidation in drug discovery
and development
Nassar, A.-E.F. / Talaat, R.E. , Drug Discovery Today, 9 (7), p.
317-327, Apr 2004
http://www.scirus.com/srsapp/sciruslink?src=sd&url=http%3A%2F%
2Fwww.sciencedirect.com%2Fscience%3F_ob%3DGatewayURL%26_origin%
3DScienceSearch%26_method%3DcitationSearch%26_piikey%
3DS1359644603030186%26_version%3D1%26_returnURL%3Dhttp%253A%252F%
252Fwww.scirus.com%252Fsrsapp%252Fsearch%253Fq%253D%2528LC-MS-NMR%
2529%252BAND%252B%2528issn%25253A13596446%2529%2526t%253Dall%2526ds%
253Dsd%2526drill%253Dno%2526p%253D0%26md5%
3D5ed781bca1fcffa0d41de8f6b9ab62ea
[URLs all one line - db]
Hope you find them suitable.
Regards,
Jignesh S. Kotecha
Scientist 1(Discovery Bioanalytical)
Torrent Research Centre,
P.O. BHAT
DIST. GANDHINAGAR
INDIA 382428
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