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The following message was posted to: PharmPK
Where can I purchase paracetamol glucuronide, paracetamol sulphate,
paracetamol cysteine and paracetamol mercapturate.
Thank you for your help.
Margaret J C Main
Research Assistant
SMCN
e-mail: m.main.-a-.abdn.ac.uk
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The following message was posted to: PharmPK
Hi,
I am trying to inject paracetamol sulfate 30ul injection for a
concentration of 300ug/ml in (ACN:H2O) 50:50,in HPLC.
I first used a metabolite stock purchased from Toronto Research
Chemical and
this did not produce a good peak so I purchased Paracetamol sulfate
potassium
salt from Sigma and again the chromatogram is all distorted. I have
referenced several papers and know approximately the time that
sulfate should
come. Are there any specific requirements or conditions in which I
am not
considering when injecting? The glucoronide metabolite produces good
peaks.
Even when I inject sulfate into plasma it still has unusual shaped
peaks.
Thanks in advance for your help.
Karen e. Thudium
Karen e. Thudium
PharmD. Student
University of Rhode Island
College of Pharmacy
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Use some buffer instead of water in mobile phase
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