Back to the Top
Dear all,
I am trying to determine whether PBPK modeling can be applied to
controlled release formulations?
can anyone shed some light on this please!!
Look forward to another interesting discussion on the same!!
Thanks in advance:-)
Back to the Top
There are at least 3 software packages on oral absorption topic.
The are all based on PBPK (compartment or tube assumption).
And some of them could be used for controlled release.
The publications were given below:
Gatroplus
www.simulations-plus.com
Yu, L.X., J.R. Crison, and G.L. Amidon, A strategic approach for
predicting oral drug absorption[J]. Pharm Res, 1995. 12: p. S8.
Yu, L.X., et al., Transport approaches to the biopharmaceutical
design of oral drug delivery systems: prediction of intestinal
absorption[J]. Adv Drug Deliv Rev, 1996. 19(3): p. 359-76.
Yu, L.X. and G.L. Amidon, Saturable small intestinal drug absorption
in humans: modeling and interpretation of cefatrizine data[J]. Eur J
Pharm Biopharm, 1998. 45(2): p. 199-203.
Yu, L.X. and G.L. Amidon, A compartmental absorption and transit
model for estimating oral drug absorption[J]. Int J Pharm, 1999. 186
(2): p. 119-25.
Yu, L.X., An integrated model for determining causes of poor oral
drug absorption[J]. Pharm Res, 1999. 16(12): p. 1883-7
Agoram, B., W.S. Woltosz, and M.B. Bolger, Predicting the impact of
physiological and biochemical processes on oral drug bioavailability
[J]. Adv Drug Deliv Rev, 2001. 50 Suppl 1: p. S41-67
PK-Sim
Willmann, S., et al., A physiologic model for simulating
gastrointestinal flow and drug absorption in rats[J]. Pharm Res,
2003. 20(11): p. 1766-71.
Willmann, S., et al., A physiological model for the estimation of the
fraction dose absorbed in humans[J]. J Med Chem, 2004. 47(16): p.
4022-31.
iDEA (?)
Grass, G.M., C.A. Bozarth, and J.J. Vallner, Evaluation of the
performance of controlled release dosage forms of ticlopidine using
in vitro intestinal permeability and computer simulations[J]. J Drug
Target, 1994. 2(1): p. 23-33.
Grass, G.M., Simulation models to predict oral drug absorption from
in vitro data[J]. Adv Drug Deliv Rev, 1997.
Norris, D.A., et al., Development of predictive pharmacokinetic
simulation models for drug discovery[J]. Journal Of Controlled
Release, 2000. 65(1-2): p. 55-62.
Guangli
Back to the Top
The following message was posted to: PharmPK
If you know the site of release and release kinetics: why not?
Jan
Back to the Top
The following message was posted to: PharmPK
Also there is acslXtreme.com software - that is very good at doing PBPK
modeling
[Boomer has some pbpk elements as well. I would imagine that you
could use WinNonlin also. One thing to note though is that you may
well be dealing with a 'stiff' system so an appropriate numerical
integration algorithm would be required - db]
Back to the Top
The following message was posted to: PharmPK
GastroPlus provides a comprehensive set of options for controlled
release as
well as PBPK modeling, including deconvolution of the in vivo release vs
time and IVIVC for in vivo release vs in vitro release, as well as the
standard IVIVC for F and Fa vs in vitro release.
As far as we know, no other IVIVC software available is capable of
providing
all of the integration provided in GastroPlus in handling complex
absorption
and PK phenomena as well as coupling with PD modeling.
Walt Woltosz
Chairman & CEO
Simulations Plus, Inc. (AMEX: SLP)
42505 10th Street West
Lancaster, CA 93534-7059
U.S.A.
http://www.simulations-plus.com
Phone: (661) 723-7723
FAX: (661) 723-5524
E-mail: walt.aaa.simulations-plus.com
Want to post a follow-up message on this topic?
If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "PBPK modeling of controlled release preparations" as the subject | Support PharmPK by using the |
Copyright 1995-2011 David W. A. Bourne (david@boomer.org)