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Dear PharmPK members,
I am planning to run a human drug-drug interaction study, using
chlorzoxazone as a probe substrate for CYP2E1 activity. So far, I have
not been able to find any published information on which to base
sample size calculation. More specifically, I am looking for the error
variance associated with log-transformed Cmax and AUC after a 250mg
oral dose of chlorzoxazone.
Could anyone help and provide a published reference?
Many thanks,
Henri
Henri MERDJAN, Pharm, AIHP
Head, Drug Metabolism and Pharmacokinetics
NOVEXEL, France
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The following message was posted to: PharmPK
Pharmacokinetic parameters of chlorzoxozone have been published in many
papers.
Try chlorzoxazone, pharmacokinetics and human in Pubmed
There is a paper with aspirin in 2006.
Susan
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