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i have a query regarding diclofenac dissolution.
what should be the ideal buffer system to check diclofenac sod
sustained release pellets-6.8 or 7.2 or 7.5, what should be the
buffering agent to prepare the buffer-sodium or potassium salt? i am
getting very variable results.also tried a large variety of polymers
but none helps to achieve desired dissolution profile in 2,4 and 6 hrs.
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