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I'm looking into doing some behavioural studies using MK-801
(dizocilpine) to induce cognitive dysfunction. Majority of studies
have used a standard dose of 0.3mg/kg but this does not seem to
produce any changes in behaviour measured using the prepulse
inhibition paradigm. Some studies have used higher doses of up 1mg/kg.
Has anyone else had this problem? Is anyone aware of any work that has
been done to investigate this dose-response relationship?
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